Supramolecular Aggregates of Amphiphilic Gadolinium Complexes as Blood Pool MRI/MRA Contrast Agents: Physicochemical Characterization
- 22 June 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 22 (15), 6635-6643
- https://doi.org/10.1021/la053500k
Abstract
In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near neutral pH in both cases, the dominant aggregates are micelles. The high negative actual charge of the surfactant headgroup causes a strong headgroups repulsion, promoting the formation of large and high curvature aggregates. By decreasing pH and less markedly increasing the ionic strength, we observe a micelle-to-vesicle transition driven by a decreased electrostatic repulsion. A straightforward switch between different aggregation states can be particularly useful in the development of pH-responsive MRA/MRI contrast agentsKeywords
This publication has 27 references indexed in Scilit:
- Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRIJournal of the American Chemical Society, 2004
- Gadolinium-Enhanced 3-Dimensional Magnetic Resonance Angiography of Pulmonary Blood Supply in Patients With Complex Pulmonary Stenosis or AtresiaCirculation, 2002
- l-Glutamic Acid and l-Lysine as Useful Building Blocks for the Preparation of Bifunctional DTPA-like LigandsBioconjugate Chemistry, 1998
- Lanthanide(III) chelates for NMR biomedical applicationsChemical Society Reviews, 1998
- Cryotransmission electron microscopy of thin vitrified samplesCurrent Opinion in Colloid & Interface Science, 1996
- Synthesis and Characterization of Chelator-Lipids for Reversible Immobilization of Engineered Proteins at Self-Assembled Lipid InterfacesJournal of the American Chemical Society, 1994
- Self-diffusion in nonionic surfactant-water systemsThe Journal of Physical Chemistry, 1991
- Solubilization of phospholipids by detergents structural and kinetic aspectsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1983
- Small-angle neutron scattering from aqueous micellar solutions of a nonionic surfactant as a function of temperatureThe Journal of Physical Chemistry, 1982
- The Acid Dissociation Constants of Diethylenetriaminepentaacetic Acid and the Stability Constants of Some of its Metal Chelates1Journal of the American Chemical Society, 1958