Pathophysiologic Cascades in Ischemic Stroke
Open Access
- 19 June 2012
- journal article
- review article
- Published by SAGE Publications in International Journal of Stroke
- Vol. 7 (5), 378-385
- https://doi.org/10.1111/j.1747-4949.2012.00839.x
Abstract
Many advances have been achieved in terms of understanding the molecular and cellular mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain elusive. In this minireview, we summarize the basics of ischemic cascades after stroke, covering neuronal death mechanisms, white matter pathophysiology, and inflammation with an emphasis on microglia. Translating promising mechanistic knowledge into clinically meaningful stroke drugs is very challenging. An integrative approach that encompasses the multimodal and multicell signaling phenomenon of stroke will be required to move forward.Keywords
This publication has 115 references indexed in Scilit:
- The immunology of stroke: from mechanisms to translationNature Medicine, 2011
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy syndrome mutations increase susceptibility to spreading depressionAnnals of Neurology, 2010
- Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental TestingJournal of Cerebral Blood Flow & Metabolism, 2010
- The Science of Stroke: Mechanisms in Search of TreatmentsNeuron, 2010
- Spreading depolarizations cycle around and enlarge focal ischaemic brain lesionsBrain, 2010
- Phosphodiesterase III Inhibition Promotes Differentiation and Survival of Oligodendrocyte Progenitors and Enhances Regeneration of Ischemic White Matter Lesions in the Adult Mammalian BrainJournal of Cerebral Blood Flow & Metabolism, 2009
- 12/15‐Lipoxygenase targets neuronal mitochondria under oxidative stressJournal of Neurochemistry, 2009
- GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-NitrosylationNeuron, 2009
- Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matterGlia, 2007
- 1,026 Experimental treatments in acute strokeAnnals of Neurology, 2006