Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules
Open Access
- 22 June 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 11 (1), 264
- https://doi.org/10.1186/1471-2407-11-264
Abstract
Although FOXO transcription factors may have an anti-angiogenic role, little is known about their role in tumor angiogenesis. The present study was performed to investigate the correlation between the constitutive expression of phosphorylated FOXO1 (pFOXO1) and angiogenesis in gastric cancer.This publication has 36 references indexed in Scilit:
- Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancerJournal of Molecular Signaling, 2010
- Overexpression of Endothelial Cell Specific Molecule-1 (ESM-1) in Gastric CancerAnnals of Surgical Oncology, 2010
- Constitutive NF-κB Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor GrowthClinical Cancer Research, 2009
- A hypoxia-independent up-regulation of hypoxia-inducible factor-1 by AKT contributes to angiogenesis in human gastric cancerCarcinogenesis: Integrative Cancer Research, 2007
- Correlative studies on bFGF mRNA and MMP-9 mRNA expressions with microvascular density, progression, and prognosis of gastric carcinomasWorld Journal of Gastroenterology, 2005
- Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient MicePublished by Elsevier BV ,2004
- HIF-1α: a Valid Therapeutic Target for Tumor TherapyCancer Research and Treatment, 2004
- Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisOncogene, 2002
- Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumorsBreast Cancer Research and Treatment, 1995
- Angiogenesis in cancer, vascular, rheumatoid and other diseaseNature Medicine, 1995