Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA by Biocompatible Approaches: Synthesis and Characterization
Open Access
- 1 January 2013
- journal article
- research article
- Published by Hindawi Limited in Advances in Materials Science and Engineering
- Vol. 2013, 1-8
- https://doi.org/10.1155/2013/328763
Abstract
In this work, a new approach was introduced to prepare interpenetrating polymer network PVA/GE hydrogels by cross-linking of various concentration gelatin in the presence of transglutaminase enzyme by using the freezing-thawing cycles technique. The effects of freezing-thawing cycles on the properties of morphological characterization, gel fraction, swelling, mechanical, and MTT assay were investigated. The IPN PVA/GE hydrogels showed excellent physical and mechanical Properties. MTT assay data and the fibroblasts culture also showed excellent biocompatibility and good proliferation. This indicates that the IPN hydrogels are stable enough for various biomedical applications.Keywords
Funding Information
- National Natural Science Foundation of China (51073036)
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