Circadian rhythm in intraocular pressure: A rabbit model
- 1 January 1981
- journal article
- Published by Taylor & Francis Ltd in Current Eye Research
- Vol. 1 (3), 169-173
- https://doi.org/10.3109/02713688109001822
Abstract
An animal model for study of the clrcadian rhythm in intraocular pressure (IOP) was developed using carefully maintained environmental lighting conditions. Highly predictable, precipitous increases and decreases in IOP of somewhat more than 10 mm Hg were found to be closely correlated with the onset of darkness and light, respectively. The daily spontaneous variations in IOP, once entrained, were maintained in constant darkness, but were eliminated by constant light, as is similarly seen in many mammalian systems. This model provides a novel means of investigating circadian IOP oscillation, which has been shown to be especially amplified in primary open angle glaucoma (POAG). This new rabbit model may also warrant consideration for use in screening ocular antihypertensive drugs since it could obviate the gross physiological manipulations and concomitant side effects inherent in the popular methods of inducing ocular hypertension in animal models.Keywords
This publication has 26 references indexed in Scilit:
- Spontaneous Trends in Ocular Pressure in Untreated Ocular HypertensionAmerican Journal of Ophthalmology, 1980
- Correlative 24-hour relationships between intraocular pressure and plasma cortisol in normal subjects and patients with glaucoma.British Journal of Ophthalmology, 1975
- Diurnal Variation of Intraocular Pressure in Primary Open-Angle GlaucomaAmerican Journal of Ophthalmology, 1975
- Diurnal Variation in Intraocular PressureAmerican Journal of Ophthalmology, 1974
- Seasonal Variation in Intraocular PressureAmerican Journal of Ophthalmology, 1970
- Bedford glaucoma survey.BMJ, 1968
- Influence of menstruation on glaucoma.British Journal of Ophthalmology, 1967
- Diurnal Tonography in Normal and Glaucomatous Eyes*American Journal of Ophthalmology, 1965
- Comparison Between Pilocarpine and Echothiophate for Chronic Simple GlaucomaAmerican Journal of Ophthalmology, 1964
- Diurnal Variation of Plasma 17-Hydroxycorticoids and Intraocular Pressure in Glaucoma*American Journal of Ophthalmology, 1962