Clinical impact of antibody formation to botulinum toxin A in children
- 26 April 2004
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 55 (5), 732-735
- https://doi.org/10.1002/ana.20098
Abstract
We studied the clinical impact of neutralizing antibodies to botulinum toxin A that occurred during long‐term treatment of children between 1993 and 2001. Antibodies were found in high titers in 35 of 110 (31.8%) samples from individual patients. Antibody formation correlated with secondary nonresponse (p < 0.001). The most significant risk factors for antibody formation were the frequency of treatments (p = 0.0001) and the injection of a higher weight‐adapted maximum dose per treatment (p = 0.001).Keywords
Funding Information
- PharmAllergan GmbH, Ettlingen, Germany
- Merz Pharmaceuticals
- Ipsen Pharma
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