A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia
- 15 June 2004
- journal article
- Published by American Society of Hematology in Blood
- Vol. 103 (12), 4672-4673
- https://doi.org/10.1182/blood-2003-11-4060
Abstract
Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism. (Blood. 2004;103:4672-4673)Keywords
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