Role of microparticles in atherothrombosis
Open Access
- 10 April 2008
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 263 (5), 528-537
- https://doi.org/10.1111/j.1365-2796.2008.01957.x
Abstract
Cell activation or apoptosis leads to plasma membrane blebbing and microparticle (MP) release in the extracellular space. MPs are submicron membrane vesicles which express a panel of phospholipids and proteins specific of the cells they are derived from. Exposure of negatively charged phospholipids and tissue factor confers a procoagulant potential to MPs. MPs accumulate in the lipid core of the atherosclertotic plaque and is a major determinant of its thrombogenecity. Elevation of plasma MPs levels, particularly those of endothelial origin, reflects cellular injury and is considered now as a surrogate marker of vascular dysfunction. Thus, MPs can be seen as triggers of a vicious circle for they promote prothrombogenic and pro‐inflammatory responses as well as cellular dysfunction within the vascular compartment. A better knowledge of MP composition and biological effects as well as the mechanisms leading to their clearance will probably open new therapeutic approaches in the treatment of atherothrombosis.Keywords
This publication has 89 references indexed in Scilit:
- Microparticles of Human Atherosclerotic Plaques Enhance the Shedding of the Tumor Necrosis Factor-α Converting Enzyme/ADAM17 Substrates, Tumor Necrosis Factor and Tumor Necrosis Factor Receptor-1The American Journal of Pathology, 2007
- P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial InfarctionClinical Chemistry, 2006
- Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery diseaseEuropean Heart Journal, 2006
- Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimizationProteomics, 2006
- Inflammation, Atherosclerosis, and Coronary Artery DiseaseNew England Journal of Medicine, 2005
- Elevated plasma endothelial microparticles: Preeclampsia versus gestational hypertensionAmerican Journal of Obstetrics and Gynecology, 2004
- Measuring circulating cell‐derived microparticlesJournal of Thrombosis and Haemostasis, 2004
- Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathwayBiochemical and Biophysical Research Communications, 2004
- Circulating procoagulant microparticles and soluble GPV in myocardial infarction treated by primary percutaneous transluminal coronary angioplasty. A possible role for GPIIb‐IIIa antagonistsJournal of Thrombosis and Haemostasis, 2004
- High levels of circulating endothelial microparticles in patients with acute coronary syndromesAmerican Heart Journal, 2003