The Anticholinergic Drug Scale as a Measure of Drug‐Related Anticholinergic Burden: Associations With Serum Anticholinergic Activity
Top Cited Papers
- 1 December 2006
- journal article
- clinical trial
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 46 (12), 1481-1486
- https://doi.org/10.1177/0091270006292126
Abstract
Anticholinergic Drug Scale (ADS) scores were previously associated with serum anticholinergic activity (SAA) in a pilot study. To replicate these results, the association between ADS scores and SAA was determined using simple linear regression in subjects from a study of delirium in 201 long-term care facility residents who were not included in the pilot study. Simple and multiple linear regression models were then used to determine whether the ADS could be modified to more effectively predict SAA in all 297 subjects. In the replication analysis, ADS scores were significantly associated with SAA (R2 = .0947, P < .0001). In the modification analysis, each model significantly predicted SAA, including ADS scores (R2 = .0741, P < .0001). The modifications examined did not appear useful in optimizing the ADS. This study replicated findings on the association of the ADS with SAA. Future work will determine whether the ADS is clinically useful for preventing anticholinergic adverse effects.Keywords
This publication has 6 references indexed in Scilit:
- Methods for Assessing Drug-Related Anticholinergic ActivityPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2005
- Bioelectrical Impedance Analysis and Other Hydration Parameters as Risk Factors for Delirium in Rural Nursing Home ResidentsThe Journals of Gerontology: Series A, 2004
- Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older AdultsArchives of Internal Medicine, 2003
- Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical InpatientsArchives of Internal Medicine, 2001
- Snipping the Thread of LifeArchives of Internal Medicine, 1989
- Serum Levels of Anticholinergic Drugs in Treatment of Acute Extrapyramidal Side EffectsArchives of General Psychiatry, 1980