False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases
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Open Access
- 1 April 2020
- journal article
- research article
- Published by The Korean Society of Radiology in Korean Journal of Radiology
- Vol. 21 (4), 505-508
- https://doi.org/10.3348/kjr.2020.0146
Abstract
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.This publication has 4 references indexed in Scilit:
- Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR TestingRadiology, 2020
- A Novel Coronavirus from Patients with Pneumonia in China, 2019The New England Journal of Medicine, 2020
- Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study GroupPublished by Cold Spring Harbor Laboratory ,2020