Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy
- 14 January 2011
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 33 (2), 251-256
- https://doi.org/10.1002/hed.21439
Abstract
Background Human papillomavirus (HPV)–related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status. Methods p16 immunohistochemistry (IHC) was assessed in archival paraffin‐embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR). Results Compared with p16‐ and HPV‐negative patients, the p16‐ and HPV‐positive patients had improved overall survival, disease‐free survival, and locoregional recurrence rates. Conclusions p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV‐related SCCHN treated with cisplatin and radiation. © 2010 Wiley Periodicals, Inc. Head Neck, 2011Keywords
This publication has 23 references indexed in Scilit:
- Radiation Response in Two HPV-Infected Head-and-Neck Cancer Cell Lines in Comparison to a Non–HPV-Infected Cell Line and Relationship to Signaling Through AKTInternational Journal of Radiation Oncology*Biology*Physics, 2009
- The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell CarcinomasInternational Journal of Radiation Oncology*Biology*Physics, 2009
- EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal CancerJournal of Clinical Oncology, 2008
- Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical TrialJNCI Journal of the National Cancer Institute, 2008
- Detection of Human Papillomavirus-16 in Fine-Needle Aspirates to Determine Tumor Origin in Patients with Metastatic Squamous Cell Carcinoma of the Head and NeckClinical Cancer Research, 2007
- A Proportional Hazards Model for the Subdistribution of a Competing RiskJournal of the American Statistical Association, 1999
- A Proportional Hazards Model for the Subdistribution of a Competing RiskJournal of the American Statistical Association, 1999
- Inference for Events with Dependent Risks in Multiple Endpoint StudiesJournal of the American Statistical Association, 1991
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958