NMDA receptor encephalitis and other antibody-mediated disorders of the synapse
- 6 December 2016
- journal article
- lecture
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 87 (23), 2471-2482
- https://doi.org/10.1212/wnl.0000000000003414
Abstract
Investigations during the last 10 years have revealed a group of disorders mediated by antibodies against ion channels and synaptic receptors, which cause both neurologic and psychiatric symptoms. In this review, I discuss the process of discovery and immunologic triggers of these disorders, and use anti-NMDA receptor encephalitis to emphasize the importance of understanding the underlying physiopathologic mechanisms in those diseases. A better knowledge of these mechanisms reveals points of convergence with other disorders (e.g., schizophrenia), suggests treatment strategies beyond immunotherapy, and is helping us understand how memories are formed and retrieved.Keywords
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