The Prefrontal Cortex and Flexible Behavior
- 1 October 2007
- journal article
- review article
- Published by SAGE Publications in The Neuroscientist
- Vol. 13 (5), 532-545
- https://doi.org/10.1177/1073858407301369
Abstract
The prefrontal cortex in primates guides behavior by selecting relevant stimuli for the task at hand, mediated through excitatory bidirectional pathways with structures associated with sensory processing, memory, and emotions. The prefrontal cortex also has a key role in suppressing irrelevant stimuli through a mechanism that is not well understood. Recent findings indicate that prefrontal pathways interface with laminar-specific neurochemical classes of inhibitory neurons in sensory cortices, terminate extensively in the frontal and sensory sectors of the inhibitory thalamic reticular nucleus, and target the inhibitory intercalated masses of the amygdala. Circuit-based models suggest that prefrontal pathways can select relevant signals and efficiently suppress distractors, in processes that are disrupted in schizophrenia and in other disorders affecting prefrontal cortices. NEUROSCIENTIST 13(5):532—545, 2007. DOI: 10.1177/1073858407301369Keywords
This publication has 66 references indexed in Scilit:
- Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdalaNeuroImage, 2006
- Diversity of laminar connections linking periarcuate and lateral intraparietal areas depends on cortical structureEuropean Journal of Neuroscience, 2006
- Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in PrimatesCerebral Cortex, 2005
- Relationship of Prefrontal Connections to Inhibitory Systems in Superior Temporal Areas in the Rhesus MonkeyCerebral Cortex, 2005
- Localization of Calcium-binding Proteins in Physiologically and Morphologically Characterized Interneurons of Monkey Dorsolateral Prefrontal CortexCerebral Cortex, 2004
- Circuits through prefrontal cortex, basal ganglia, and ventral anterior nucleus map pathways beyond motor controlThalamus & Related Systems, 2004
- Structure and connections of the thalamic reticular nucleus: Advancing views over half a centuryJournal of Comparative Neurology, 2003
- The Thalamic Reticular Nucleus: More Than a Sensory Nucleus?The Neuroscientist, 2002
- Contralateral thalamic projections predominantly reach transitional cortices in the rhesus monkeyJournal of Comparative Neurology, 1994
- GABAergic Neurons and Their Role in Cortical Plasticity in PrimatesCerebral Cortex, 1993