Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci
Open Access
- 1 October 2012
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (19), 10873-10879
- https://doi.org/10.1128/jvi.01506-12
Abstract
Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions and viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.This publication has 25 references indexed in Scilit:
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