Cryptic gluten intolerance in type 1 diabetes: identifying suitable candidates for a gluten free diet
Open Access
- 1 January 2006
- Vol. 55 (1), 133-134
- https://doi.org/10.1136/gut.2005.077511
Abstract
We have used a phage display assay8 to show that in CD patients, production of anti-tTG is limited to the intestine. Here, we monitored the effects of a gluten free diet (GFD) on anti-tTG antibody synthesis in the intestinal mucosa of a diabetic adult and a boy at high risk of diabetes, both carrying HLA DQ2/DQ8, but lacking serum anti-tTG. Intestinal specimens from both subjects and samples of peripheral blood lymphocytes were used to make phage-antibody libraries8 to look for lymphocytes synthesising anti-tTG antibodies.Keywords
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