New checkpoints in cancer immunotherapy
- 4 March 2017
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 276 (1), 52-65
- https://doi.org/10.1111/imr.12524
Abstract
Immune responses must be fine-tuned to allow effective clearance of invading pathogens, while maintain tolerance to self-antigens. T cells are the major effector cells for fighting and killing tumor cells. Immune checkpoints play a pivotal role in T cell activation, and determine the functional outcome of T cell receptor (TCR) signaling. The blockade of immune checkpoints CTLA-4 and PD-1 has already been one of the most successful cancer immunotherapies. In this review, we will focus on three novel inhibitory B7 family checkpoint molecules, B7-H3, B7S1 and VISTA. The aim of this article is to summarize their expressions in tumors as well as their roles in controlling and suppressing T cell immune responses and anti-tumor immunity. These pathways may be explored in future cancer immunotherapy.Keywords
Funding Information
- National Natural Science Foundation of China (81502462)
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