Tumour thickness as a predictor of occult lymph node metastases in patients with stage I and II melanoma undergoing sentinel lymph node biopsy
- 1 October 2002
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 89 (10), 1223-1227
- https://doi.org/10.1046/j.1365-2168.2002.02236.x
Abstract
Background Sentinel lymph node biopsy (SLNB) is a minimally invasive procedure used accurately to stage nodal basins at risk of occult metastases. There are no data as yet to show a survival benefit from SLNB and its use remains controversial. If Breslow thickness of the tumour correlates well with positive SLNB, it could be used to select patients for SLNB. Methods A quantitative systematic review of published studies on SLNB in patients with melanoma available by September 2001 was performed. Results Twelve studies containing 4218 patients with stage I and II melanoma were identified; 17·8 (95 per cent confidence interval 16·7 to 19·0) per cent of patients had nodal micrometastases detected by SLNB. The incidence of micrometastasis in sentinel nodes correlated directly with Breslow tumour thickness; it was 1·0 per cent for lesions of less than or equal to 0·75 mm, 8·3 per cent for 0·76–1·50 mm, 22·7 per cent for 1·51–4·0 mm and 35·5 per cent for more than 4·0 mm. Conclusion The Breslow thickness of primary melanoma predicts the presence of a sentinel node metastasis. The published data are not sufficient to demonstrate a correlation between other known prognostic indicators and a positive SLNB.Keywords
This publication has 29 references indexed in Scilit:
- Factors that predict the presence of sentinel lymph node metastasis in patients with melanomaSurgery, 2001
- Sentinel lymph node micrometastasis and other histologic factors that predict outcome in patients with thicker melanomasJournal of the American Academy of Dermatology, 2001
- Malignant melanoma: clinical variants and prognostic indicatorsClinical and Experimental Dermatology, 2000
- Sentinel node biopsy and ultrasound scanning in cutaneous melanoma: clinical and technical considerationsEuropean Journal Of Cancer, 2000
- Reliability of sentinel lymph node biopsy for staging melanomaBritish Journal of Surgery, 2000
- Sentinel node localization in primary melanoma: Preoperative dynamic lymphoscintigraphy, intraoperative gamma probe, and vital dye guidanceSurgery, 2000
- Cancer statistics, 2000CA: A Cancer Journal for Clinicians, 2000
- Minimal-Access Surgery for Staging of Malignant MelanomaArchives of Surgery, 1995
- Technical Details of Intraoperative Lymphatic Mapping for Early Stage MelanomaArchives of Surgery, 1992
- A subset in which Level Is the Major Prognostic IndicatorAnnals of Surgery, 1985