Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Open Access
- 1 November 2005
- journal article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 280 (47), 39260-39267
- https://doi.org/10.1074/jbc.m506407200
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein PrimerJournal of Virology, 2005
- HCV NS5b RNA-Dependent RNA Polymerase Inhibitors: From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and SynthesisJournal of Medicinal Chemistry, 2004
- The Crystal Structure of the RNA-Dependent RNA Polymerase from Human RhinovirusStructure, 2004
- Crystal Structure of Norwalk Virus Polymerase Reveals the Carboxyl Terminus in the Active Site CleftJournal of Biological Chemistry, 2004
- Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass SpectrometryAnalytical Chemistry, 2004
- Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potencyBioorganic & Medicinal Chemistry Letters, 2004
- Characterization of the Inhibition of Hepatitis C Virus RNA Replication by NonnucleosidesJournal of Virology, 2004
- Modulation of Hepatitis C Virus RNA-dependent RNA Polymerase Activity by Structure-based Site-directed MutagenesisJournal of Biological Chemistry, 2002
- Bacteriophage φ6 RNA-dependent RNA PolymeraseJournal of Biological Chemistry, 2002
- Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA PolymeraseJournal of Biological Chemistry, 2002