Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP‐dependent kinase
Open Access
- 6 April 2010
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 24 (8), 2620-2630
- https://doi.org/10.1096/fj.09-152546
Abstract
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP, is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change...Keywords
Funding Information
- Alexander S. Onassis Public Benefit Foundation
- Massachusetts Lions Eye Research Fund
- Research to Prevent Blindness
- National Institutes of Health (NIH EY009294)
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