Polyphasic Identification and Susceptibility to Seven Antifungals of 102 Aspergillus Isolates Recovered from Immunocompromised Hosts in Greece
Open Access
- 1 June 2011
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 55 (6), 3025-3030
- https://doi.org/10.1128/aac.01491-10
Abstract
In this study, the first such study in Greece, we used polyphasic identification combined with antifungal susceptibility study to analyze Aspergillus clinical isolates comprising 102 common and rare members of sections Fumigati, Flavi, Terrei, Nidulantes, Nigri, Circumdati, Versicolores, and Usti. High amphotericin B MICs (>2 μg/ml) were found for 17.6% of strains. Itraconazole, posaconazole, and voriconazole MICs of >4 μg/ml were shown in 1%, 5%, and 0% of the isolates, respectively. Anidulafungin, micafungin, and caspofungin minimum effective concentrations (MECs) of ≥2 μg/ml were correspondingly recorded for 4%, 9%, and 33%, respectively, of the strains.Keywords
This publication has 25 references indexed in Scilit:
- Use of Epidemiological Cutoff Values To Examine 9-Year Trends in Susceptibility of Aspergillus Species to the TriazolesJournal of Clinical Microbiology, 2011
- Wild-Type MIC Distributions and Epidemiological Cutoff Values for the Triazoles and Six Aspergillus spp. for the CLSI Broth Microdilution Method (M38-A2 Document)Journal of Clinical Microbiology, 2010
- Wild-Type MIC Distribution and Epidemiological Cutoff Values for Aspergillus fumigatus and Three Triazoles as Determined by the Clinical and Laboratory Standards Institute Broth Microdilution MethodsJournal of Clinical Microbiology, 2009
- In Vitro Susceptibility of Clinical Isolates of Aspergillus spp. to Anidulafungin, Caspofungin, and Micafungin: a Head-to-Head Comparison Using the CLSI M38-A2 Broth Microdilution MethodJournal of Clinical Microbiology, 2009
- Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance NetworkJournal of Clinical Microbiology, 2009
- Frequency and Evolution of Azole Resistance inAspergillus fumigatusAssociated with Treatment Failure1Emerging Infectious Diseases, 2009
- Sequence-Based Identification of Aspergillus, Fusarium , and Mucorales Species in the Clinical Mycology Laboratory: Where Are We and Where Should We Go from Here?Journal of Clinical Microbiology, 2009
- Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole EraAntimicrobial Agents and Chemotherapy, 2008
- Comparative In Vitro Pharmacodynamics of Caspofungin, Micafungin, and Anidulafungin against Germinated and Nongerminated Aspergillus ConidiaAntimicrobial Agents and Chemotherapy, 2008
- Aspergillus species identification in the clinical settingStudies in Mycology, 2007