SPECIFIC KERATINS AS MOLECULAR MARKERS FOR NEOPLASMS WITH A STRATIFIED EPITHELIAL ORIGIN
- 1 January 1984
- journal article
- research article
- Vol. 44 (4), 1600-1603
Abstract
The expression of specific keratin polypeptides in human neoplasms was investigated by the immunoblot technique using monoclonal anti-keratin antibodies, MW 50,000 and 58,000 keratins, recognized by AE1 and AE3 antibodies, respectively, were detected only in carcinomas of stratified epithelial origin, but not in carcinomas derived from simple epithelia. No keratin was detected in nonepithelial tumors including melanoma, lymphoma, neurofibroma and sarcoma. The MW 50,000 and 58,000 keratins provide useful molecular markers for identifying neoplasms of stratified squamous epithelial origin.This publication has 19 references indexed in Scilit:
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