Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF‐α mRNA expression in human monocytes by allicin
- 7 April 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (10), 2517-2522
- https://doi.org/10.1016/j.febslet.2006.03.071
Abstract
Chronic inflammation associated with tumor necrosis factor (TNF)-α and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-α. We show the augmented expression of TNF-α mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-α in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.Keywords
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