Influence of Pharmacokinetic Model on Vancomycin Peak Concentration Targets
- 1 April 1996
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Therapeutic Drug Monitoring
- Vol. 18 (2), 145-148
- https://doi.org/10.1097/00007691-199604000-00006
Abstract
The aim of this study was to adapt the vacomycin therapeutic range to the kinetic models usually employed in clinical settings (one- and two-compartment models). Estimates of vancomycin pharmacokinetic parameters were obtained for both models in 22 hematologically malignant patients on vancomycin treatment using two serum concentrations and a bayesian algorithm. From these individually estimated pharmacokinetic parameters, an estimation of the maximum (Cmaxss), 2 h postinfusion (C2ss), and minimum (Cminss) steady-state vancomycin serum concentrations for the one- and two-compartment models was made for a fixed 30 mg/kg/day dose. The linear regression equations between the predicted C2ss and Cminss for the one- and two-compartment models do not differ significantly from the identity line, whereas the corresponding equation for Cmaxss points to a 61% underestimation of Cmaxss when the one-compartment model is used. From this latter regression equation, it is possible to define 20 mg/L (range of 18-21 mg/L) as a target Cmaxss vancomycin serum concentration when a one-compartment model is used to monitor vancomycin therapy. Another practical approach would be to define the target concentration by a desired range at 2 h, which corresponds to a Cmaxss value of 30-40 mg/L.Keywords
This publication has 12 references indexed in Scilit:
- Impact of Vancomycin Therapeutic Drug Monitoring on Patient CareAnnals of Pharmacotherapy, 1994
- Correlation of Aminoglycoside and Vancomycin Pharmacokinetic ParametersAnnals of Pharmacotherapy, 1993
- Vancomycin Therapeutic Drug MonitoringAnnals of Pharmacotherapy, 1993
- An Updated Comparison of Drug Dosing MethodsClinical Pharmacokinetics, 1991
- Errors in Assuming a One-Compartment Model for VancomycinTherapeutic Drug Monitoring, 1990
- Short Communication; Using Clinical Data to Determine Vancomycin Dosing ParametersTherapeutic Drug Monitoring, 1990
- Individualizing Vancomycin Dosage RegimensTherapeutic Drug Monitoring, 1989
- Survey of Vancomycin Monitoring Guidelines in Illinois HospitalsDrug Intelligence & Clinical Pharmacy, 1988
- Comparison of Serum Sampling Methods for Determining Vancomycin Dosage RegimensTherapeutic Drug Monitoring, 1988
- Monitoring Vancomycin TherapyDrug Intelligence & Clinical Pharmacy, 1986