Functional Maps of Human Auditory Cortex: Effects of Acoustic Features and Attention
Open Access
- 13 April 2009
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 4 (4), e5183
- https://doi.org/10.1371/journal.pone.0005183
Abstract
While human auditory cortex is known to contain tonotopically organized auditory cortical fields (ACFs), little is known about how processing in these fields is modulated by other acoustic features or by attention. We used functional magnetic resonance imaging (fMRI) and population-based cortical surface analysis to characterize the tonotopic organization of human auditory cortex and analyze the influence of tone intensity, ear of delivery, scanner background noise, and intermodal selective attention on auditory cortex activations. Medial auditory cortex surrounding Heschl's gyrus showed large sensory (unattended) activations with two mirror-symmetric tonotopic fields similar to those observed in non-human primates. Sensory responses in medial regions had symmetrical distributions with respect to the left and right hemispheres, were enlarged for tones of increased intensity, and were enhanced when sparse image acquisition reduced scanner acoustic noise. Spatial distribution analysis suggested that changes in tone intensity shifted activation within isofrequency bands. Activations to monaural tones were enhanced over the hemisphere contralateral to stimulation, where they produced activations similar to those produced by binaural sounds. Lateral regions of auditory cortex showed small sensory responses that were larger in the right than left hemisphere, lacked tonotopic organization, and were uninfluenced by acoustic parameters. Sensory responses in both medial and lateral auditory cortex decreased in magnitude throughout stimulus blocks. Attention-related modulations (ARMs) were larger in lateral than medial regions of auditory cortex and appeared to arise primarily in belt and parabelt auditory fields. ARMs lacked tonotopic organization, were unaffected by acoustic parameters, and had distributions that were distinct from those of sensory responses. Unlike the gradual adaptation seen for sensory responses, ARMs increased in amplitude throughout stimulus blocks. The results are consistent with the view that medial regions of human auditory cortex contain tonotopically organized core and belt fields that map the basic acoustic features of sounds while surrounding higher-order parabelt regions are tuned to more abstract stimulus attributes. Intermodal selective attention enhances processing in neuronal populations that are partially distinct from those activated by unattended stimuli.This publication has 97 references indexed in Scilit:
- Neural Response Properties of Primary, Rostral, and Rostrotemporal Core Fields in the Auditory Cortex of Marmoset MonkeysJournal of Neurophysiology, 2008
- Level Invariant Representation of Sounds by Populations of Neurons in Primary Auditory CortexJournal of Neuroscience, 2008
- Accurate prediction of V1 location from cortical folds in a surface coordinate systemNeuroImage, 2008
- Auditory Cortex Mapmaking: Principles, Projections, and PlasticityNeuron, 2007
- Distributed cortical networks for focused auditory attention and distractionNeuroscience Letters, 2007
- Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noiseHuman Brain Mapping, 2006
- Mapping an intrinsic MR property of gray matter in auditory cortex of living humans: A possible marker for primary cortex and hemispheric differencesNeuroImage, 2006
- Functional Imaging Reveals Numerous Fields in the Monkey Auditory CortexPLoS Biology, 2006
- Volumetric vs. surface-based alignment for localization of auditory cortex activationNeuroImage, 2005
- Functional MRI of human auditory cortex using block and event-related designsMagnetic Resonance in Medicine, 2001