Peripheral delivery of a ROCK inhibitor improves learning and working memory.
- 1 January 2009
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 123 (1), 218-223
- https://doi.org/10.1037/a0014260
Abstract
Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.Keywords
Funding Information
- Evelyn F. McKnight Brain Research Foundation
- National Institutes of Health (AG19610, NS059873)
- State of Arizona
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