Mitochondrial biogenesis in neurodegeneration
- 16 March 2017
- journal article
- review article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 95 (10), 2025-2029
- https://doi.org/10.1002/jnr.24042
Abstract
Mitochondria play a key role in energy production, calcium homeostasis, cell survival, and death. Adverse stimulations including neurodegenerative diseases may result in mitochondrial dynamic imbalance, free radical production, calcium accumulation, intrinsic cell death pathway activation and eventually cell death. Therefore, preserving or promoting mitochondrial function is a potential therapeutic target for the treatment of neurodegenerative disorders. Mitochondrial biogenesis is a process by which new mitochondria are produced from existing mitochondria. This biogenesis process is regulated by Peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1alpha (PGC-1α). Once being activated by either phosphorylation or de-acetylation, PGC-1α activates nuclear respiratory factor 1 and 2 (NRF1 and NRF2), and subsequently mitochondrial transcription factor A (Tfam). The activation of this PGC-1α - NRF –Tfam pathway leads to synthesis of mitochondrial DNA and proteins and generation of new mitochondria.Keywords
Funding Information
- National Natural Science Foundation of China (81460182)
This publication has 18 references indexed in Scilit:
- The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in PathophysiologyPhysiological Reviews, 2015
- Overexpression of human selenoprotein H in neuronal cells enhances mitochondrial biogenesis and function through activation of protein kinase A, protein kinase B, and cyclic adenosine monophosphate response element-binding protein pathwayThe International Journal of Biochemistry & Cell Biology, 2013
- Selenite Stimulates Mitochondrial Biogenesis Signaling and Enhances Mitochondrial Functional Performance in Murine Hippocampal Neuronal CellsPLOS ONE, 2012
- Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemiaBMC Neuroscience, 2012
- Activity of the mitochondrial calcium uniporter varies greatly between tissuesNature Communications, 2012
- Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performanceMitochondrion, 2011
- Caffeine activates preferentially α1-isoform of 5′AMP-activated protein kinase in rat skeletal muscleActa Physiologica, 2011
- Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards NeuroprotectionCurrent Neurovascular Research, 2009
- Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent MechanismJournal of Neuroscience, 2008
- Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression PatternOnline Journal of Public Health Informatics, 2007