Free Radical-induced Cross-linking of Polydeoxythymidylic Acid in Deoxygenated Aqueous Solution
- 1 January 1985
- journal article
- Published by Informa UK Limited in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 49 (1), 67-75
- https://doi.org/10.1080/09553008514552241
Abstract
Radiation-generated hydroxyl radicals and hydrogen atoms were shown to induce the cross-linking of polydeoxythymidylic acid (mol X wt approximately 170 000) in N2O-saturated acqueous solution. The irradiated samples were hydrolysed with formic acid and then analysed by high performance liquid chromatography. Products were isolated and subsequently characterized by capillary gas chromatography-mass spectrometry. The presence of previously described monomeric thymine products was also shown. Yields were determined and mechanisms of formation were described for the products.Keywords
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