Arterial Transit Time Mapping Obtained by Pulsed Continuous 3D ASL Imaging with Multiple Post-Label Delay Acquisitions: Comparative Study with PET-CBF in Patients with Chronic Occlusive Cerebrovascular Disease
Open Access
- 8 June 2016
- journal article
- clinical trial
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 11 (6), e0156005
- https://doi.org/10.1371/journal.pone.0156005
Abstract
Arterial transit time (ATT) is most crucial for measuring absolute cerebral blood flow (CBF) by arterial spin labeling (ASL), a noninvasive magnetic resonance (MR) perfusion assessment technique, in patients with chronic occlusive cerebrovascular disease. We validated ASL-CBF and ASL-ATT maps calculated by pulsed continuous ASL (pCASL) with multiple post-label delay acquisitions in patients with occlusive cerebrovascular disease. Fifteen patients underwent MR scans, including pCASL, and positron emission tomography (PET) scans with 15O-water to obtain PET-CBF. MR acquisitions with different post-label delays (1.0, 1.5, 2.0, 2.5 and 3.0 sec) were also obtained for ATT correction. The theoretical framework of 2-compartmental model (2CM) was also used for the delay compensation. ASL-CBF and ASL-ATT were calculated based on the proposed 2CM, and the effect on the CBF values and the ATT correction characteristics were discussed. Linear regression analyses were performed both on pixel-by-pixel and region-of-interest bases in the middle cerebral artery (MCA) territory. There were significant correlations between ASL-CBF and PET-CBF both for voxel values (r = 0.74 ± 0.08, slope: 0.87 ± 0.22, intercept: 6.1 ± 4.9) and for the MCA territorial comparison in both affected (R2 = 0.67, y = 0.83x + 6.3) and contralateral sides (R2 = 0.66, y = 0.74x + 6.3). ASL-ATTs in the affected side were significantly longer than those in the contralateral side (1.51 ± 0.41 sec and 1.12 ± 0.30 sec, respectively, p <0.0005). CBF measurement using pCASL with delay compensation was feasible and fairly accurate even in altered hemodynamic states.Funding Information
- Japan Society for the Promotion of Science (23591757, 15K09916)
- Eizai Co. Ltd.
This publication has 35 references indexed in Scilit:
- Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke — Comparison with dynamic susceptibility contrast enhanced perfusion imagingNeuroImage: Clinical, 2013
- Arterial spin labeling in patients with chronic cerebral artery steno-occlusive disease: Correlation with 15O-PETActa Radiologica, 2013
- Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imagingMagnetic Resonance in Medicine, 2011
- Arterial Spin Labeling Perfusion MRI at Multiple Delay Times: A Correlative Study with H215O Positron Emission Tomography in Patients with Symptomatic Carotid Artery OcclusionJournal of Cerebral Blood Flow & Metabolism, 2009
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008
- Modeling and optimization of look‐locker spin labeling for measuring perfusion and transit time changes in activation studies taking into account arterial blood volumeMagnetic Resonance in Medicine, 2008
- Model‐free arterial spin labeling quantification approach for perfusion MRIMagnetic Resonance in Medicine, 2006
- Efficiency of inversion pulses for background suppressed arterial spin labelingMagnetic Resonance in Medicine, 2005
- Perfusion imagingMagnetic Resonance in Medicine, 1992
- Reduction in regional cerebral metabolic rate of oxygen during human aging.Stroke, 1986