Converting enzyme inhibition in essential hypertension: the hypotensive response does not reflect only reduced angiotensin II formation.
- 1 March 1979
- journal article
- meeting abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 1 (2), 106-111
- https://doi.org/10.1161/01.hyp.1.2.106
Abstract
To determine the relative importance of hormonal factors in mediating the hypotensive response to converting enzyme inhibition (CEI), plasma renin activity (PRA), angiotensin II, and bradykinin responses to SQ20,881 were measured in 20 supine patients with essential hypertension in balance on a 10 mEq sodium diet. Patients were divided into two groups according to their diastolic blood pressure response: responders had a decrement in diastolic pressure which exceeded 9 mm Hg, the upper value of the 95% confidence limits for normotensive patients studied under similar conditions; nonresponders did not. Compared to the nonresponders, responders not only had a higher control PRA (8.7 +/- 1.7 ng/ml/hr vs 4.8 +/- 2.1, p < 0.05) and larger decrement in plasma angiotensin II (18.7 +/- 4.9 pg/ml vs 3.2 +/- 1.7, p < 0.01), but also had a higher control bradykinin (3.2 +/- 0.7 ng/ml vs 1.1 +/- 0.2, p < 0.05) and larger increment in bradykinin (4.5 +/- 1.3 ng/ml vs 1.0 +/- 0.4, p < 0.05) following SQ20,881. Because SQ20,881 altered both angiotensin II and bradykinin concentrations, we assessed the contribution of blockade of angiotensin II formation by administering angiotensin II infusions to seven responders during coverting enzyme blockade, with the angiotensin II dose adjusted to restore diastolic pressure to control levels. The plasma angiotensin II level required to return blood pressure to control was 45 +/- 15 pg/ml higher than the control plasma angiotensin II level (p < 0.01), suggesting that some other factor(s), perhaps bradykinin, are also responsible for the hypotensive response to converting enzyme inhibition.Keywords
This publication has 9 references indexed in Scilit:
- Inhibition of angiotensin converting enzyme by SQ 14,225 in conscious rabbitsEuropean Journal of Pharmacology, 1977
- Renal vascular response to interruption of the renin-angiotensin system in normal manKidney International, 1977
- Accentuated Vascular and Endocrine Response to Sq 20881 in HypertensionThe New England Journal of Medicine, 1977
- Possible Role of Renin in Hypertension as Suggested by Renin-Sodium Profiling and Inhibition of Converting EnzymeThe New England Journal of Medicine, 1977
- Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.JCI Insight, 1976
- Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture.JCI Insight, 1975
- Use of an Angiotensin II Antagonist (Saralasin) in the Recognition of “Angiotensinogenic” HypertensionThe New England Journal of Medicine, 1975
- Some Properties of Angiotensin Converting Enzyme in the Lung in vivoNature, 1970
- Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog LungNature, 1968