Hazards of Hazard Ratios — Deviations from Model Assumptions in Immunotherapy
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- 22 March 2018
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 378 (12), 1158-1159
- https://doi.org/10.1056/nejmc1716612
Abstract
Summary statistics, such as hazard ratios, that are based on models may be difficult to interpret if there are substantial departures from key assumptions, including the assumption of proportionality of hazard functions. Recent cancer immunotherapy trials provide a contemporary example.Keywords
Funding Information
- Burroughs Wellcome Fund (Innovations in Regulatory Science Award)
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