Bone marrow changes in adolescent girls with anorexia nervosa
Open Access
- 19 January 2010
- journal article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 25 (2), 298-304
- https://doi.org/10.1359/jbmr.090805
Abstract
Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We performed right knee magnetic resonance imaging (MRI) on a 1.0 T extremity scanner in 20 patients and 20 healthy controls, aged 16.2 ± 1.6 years (mean ± SD). Coronal T1-weighted (T1W) images and T1 maps were generated from T1 relaxometry images. Blinded radiologists visually assessed RM in the distal femoral and proximal tibial metaphyses in T1W images using a scale of signal intensity from 0 (homogeneous hyperintensity, no RM) to 4 (all dark, complete RM). Subjects with AN exhibited nearly twofold lower metaphyseal RM scores in both the femur (0.64 versus 1.22, p = .03) and tibia (0.54 versus 0.96, p = .08). In relaxometric measurements of four selected regions (femur and tibia amd epiphysis and metaphysis), subjects with AN showed higher mean epiphyseal but lower metaphyseal T1. The net AN-control difference between epiphysis and metaphysis was 70 ms in the femur (+31 versus −35 ms, p = .02) and of smaller magnitude in the tibia. In relaxometry data from the full width of the femur adjacent to the growth plate, AN subjects showed mean T1 consistently lower than in controls by 30 to 50 ms in virtually every part of the sampling region. These findings suggest that adolescents with AN exhibit premature conversion of hematopoietic to fat cells in the marrow of the peripheral skeleton potentially owing to adipocyte over osteoblast differentiation in the mesenchymal stem cell pool. © 2010 American Society for Bone and Mineral ResearchKeywords
This publication has 41 references indexed in Scilit:
- Increased Bone Marrow Fat in Anorexia NervosaJournal of Clinical Endocrinology & Metabolism, 2009
- PPARG by Dietary Fat Interaction Influences Bone Mass in Mice and HumansJournal of Bone and Mineral Research, 2008
- Reciprocal Relation between Marrow Adiposity and the Amount of Bone in the Axial and Appendicular Skeleton of Young AdultsJournal of Clinical Endocrinology & Metabolism, 2008
- Long‐Term Skeletal Effects of Eating Disorders with Onset in AdolescenceAnnals of the New York Academy of Sciences, 2008
- Playing with bone and fatJournal of Cellular Biochemistry, 2006
- Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation programBone, 2004
- High affinity leptin receptors are present in human mesenchymal stem cells (MSCs) derived from control and osteoporotic donorsJournal of Cellular Biochemistry, 2004
- Bone Marrow Changes in Anorexia Nervosa Are Correlated With the Amount of Weight Loss and Not With Other Clinical FindingsAmerican Journal of Clinical Pathology, 2002
- Compressive Strength Characteristics of the Human Vertebral CentrumSpine, 1977
- Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose TissuePublished by Ovid Technologies (Wolters Kluwer Health) ,1971