Endothelin and the Renal Vasculature
- 30 August 2011
- book chapter
- review article
- Published by S. Karger AG in Contributions to nephrology
- Vol. 172, 35-49
- https://doi.org/10.1159/000328720
Abstract
The endothelin (ET) system comprises a family of three isopeptides (ET-1, ET-2, and ET-3)involved in diverse physiological and pathophysiological events. ET-1 is the major renal peptide that exerts its biological activity by binding to ETA and ETB receptors. Both ETA and ETB receptors are expressed by renal microvascular smooth muscle cells, where activation causes vasoconstriction. ETB receptors are also expressed by microvascular endothelial cells, where activation leads to vasodilator responses. ET-1 influences preglomerular and postglomerular microvascular tone and thus can significantly influence renal hemodynamics. Alteration of renal ET-1 synthesis and receptor expression has been reported in cardiovascular diseases, and could contribute to renal injury by altering renal microvascular reactivity. In this brief review, we will try to summarize what is known about ET control of renal microvascular function.This publication has 46 references indexed in Scilit:
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