Ocular Surface Squamous Neoplasia
- 1 December 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Cornea
- Vol. 32 (12), 1558-1561
- https://doi.org/10.1097/ico.0b013e3182a6ea6c
Abstract
Purpose: To evaluate the current standard of care of ophthalmologists who are likely to encounter ocular surface squamous neoplasia (OSSN) in their practices and to compare this with data gathered in 2003. Methods: Invitations to a web-based survey were sent to members of the Ocular Microbiology and Immunology Group. In addition, the survey was posted to the Cornea Society Listserv, Keranet. The survey contained questions regarding the surgical and medical management of OSSN and postcare follow-up. The results of this survey were compared with the results of a 2003 survey, where possible, to identify the areas of change in the standard of care. Results: Eighty-one ophthalmologists participated in the survey. Seventy-nine percent of the responders thought that there was enough evidence for topical monotherapy in OSSN, but only 58% reported ever using topical agents as monotherapy. First-line topical therapy was interferon α2b (56%) followed by mitomycin C (MMC) (37%). A shift from surgical excision alone to excision followed by topical therapy was seen when comparing the 2012 survey to the 2003 survey. The preferred postexcision topical agent was MMC. Seventy-five percent of responders evaluate their patients every 2 to 4 months during the first 2 years. Conclusions: Topical agents were being used more in 2012, either in combination with surgical excision or as monotherapy, compared with those used in 2003. Interferon has replaced MMC as the agent most used for topical monotherapy, possibly because of a favorable safety and tolerance profile. Prospective randomized trials are needed to better define the ideal practice patterns.Keywords
This publication has 32 references indexed in Scilit:
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasiaEye, 2011
- Ocular surface squamous neoplasia in xeroderma pigmentosum: clinical spectrum and outcomeAlbrecht von Graefes Archiv für Ophthalmologie, 2011
- Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United StatesInternational Journal of Cancer, 2008
- Clinical survey of 1643 melanocytic and nonmelanocytic conjunctival tumorsOphthalmology, 2004
- Ocular Surface Squamous NeoplasiaCornea, 2003
- P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumorsCurrent Eye Research, 1997
- Ocular surface squamous neoplasiaSurvey of Ophthalmology, 1995
- Risk Factors in the Development of Ocular Surface Epithelial DysplasiaOphthalmology, 1994
- Incidence of Ocular Surface Epithelial Dysplasia in Metropolitan BrisbaneAmerican Journal of Ophthalmology, 1992
- Conjunctival and Corneal Intraepithelial and Invasive NeoplasiaOphthalmology, 1986