Meeting Report: Summary of IARC Monographs on Formaldehyde, 2-Butoxyethanol, and 1- tert -Butoxy-2-Propanol
- 1 September 2005
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 113 (9), 1205-1208
- https://doi.org/10.1289/ehp.7542
Abstract
An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent’s potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, “strong but not sufficient” evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be-published as Volume 88 of the IARC Monographs.Keywords
This publication has 51 references indexed in Scilit:
- The Science and Practice of Carcinogen Identification and EvaluationEnvironmental Health Perspectives, 2004
- Inhalation toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether in rats and miceToxicology, 2004
- Results of a 28-month chronic inhalation toxicity study of formaldehyde in male fisher-344 rats.The Journal of Toxicological Sciences, 1997
- Mortality of U.S. Embalmers and funeral directorsAmerican Journal of Industrial Medicine, 1990
- Formaldehyde: An Experimental Multipotential CarcinogenToxicology and Industrial Health, 1989
- Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehydeJournal of Applied Toxicology, 1989
- More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gasToxicology and Applied Pharmacology, 1986
- The Mortality of Ontario Undertakers and a Review of Formaldehyde-Related Mortality StudiesJournal of Occupational and Environmental Medicine, 1984
- Mortality patterns among embalmersInternational Journal of Cancer, 1983
- Formaldehyde and tumors in hamster respiratory tractToxicology, 1982