Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss
Open Access
- 20 February 2017
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 8, 77
- https://doi.org/10.3389/fphar.2017.00077
Abstract
Diseases/conditions with diverse etiology, such as hemoglobinopathies, hereditary hemochromatosis and menopause, could lead to chronic iron accumulation. This condition is frequently associated with a bone phenotype; characterized by low bone mass, osteoporosis/osteopenia, altered microarchitecture and biomechanics, and increased incidence of fractures. Osteoporotic bone phenotype constitutes a major complication in patients with iron overload. The purpose of this review is to summarize what we have learnt about iron overload-associated bone loss from clinical studies and animal models. Bone is a metabolically active tissue that undergoes continuous remodeling with the involvement of osteoclasts that resorb mineralized bone, and osteoblasts that form new bone. Growing evidence suggests that both increased bone resorption and decreased bone formation are involved in the pathological bone-loss in iron overload conditions. We will discuss the cellular and molecular mechanisms that are involved in this detrimental process. Fuller understanding of this complex mechanism may lead to the development of improved therapeutics meant to interrupt the pathologic effects of excess iron on bone.Keywords
Funding Information
- Nemzeti Kutatási és Technológiai Hivatal (K116024)
- European Social Fund (GINOP-2.3.2-15-2016-00005)
This publication has 115 references indexed in Scilit:
- Bone loss caused by iron overload in a murine model: importance of oxidative stressBlood, 2010
- Changes in Bone Microarchitecture and Biomechanical Properties in the th3 Thalassemia Mouse are Associated with Decreased Bone Turnover and Occur During the Period of Bone AccrualCalcified Tissue International, 2010
- Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?Antioxidants and Redox Signaling, 2009
- Bone Disease in Thalassemia: A Frequent and Still Unresolved ProblemJournal of Bone and Mineral Research, 2009
- Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemiaBone, 2008
- Light and shadows in the iron chelation treatment of haematological diseasesBritish Journal of Haematology, 2007
- Biology of RANK, RANKL, and osteoprotegerinArthritis Research & Therapy, 2007
- Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosisNature Genetics, 2002
- Epidemiology and outcomes of osteoporotic fracturesThe Lancet, 2002
- Hip fractures in the elderly: A world-wide projectionOsteoporosis International, 1992