Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling
- 4 January 2010
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 588 (1), 107-116
- https://doi.org/10.1113/jphysiol.2009.178905
Abstract
In the central nervous system, most excitatory synapses occur on dendritic spines, which are small protrusions from the dendritic tree. In the mature cortex and hippocampus, dendritic spines are heterogeneous in shape. It has been shown that the shapes of the spine can affect synapse stability and synaptic function. Dendritic spines are highly motile structures that can undergo actin-dependent shape changes, which occur over a time scale ranging from seconds to tens of minutes or even days. The formation, remodelling and elimination of excitatory synapses on dendritic spines represent ways of refining the microcircuitry in the brain. Here I review the current knowledge on the effects of modulation of AMPA and NMDA ionotropic glutamate receptors on dendritic spine formation, motility and remodelling.Keywords
This publication has 96 references indexed in Scilit:
- Biphasic Synaptic Ca Influx Arising from Compartmentalized Electrical Signals in Dendritic SpinesPLoS Biology, 2009
- Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic ApproachNeuron, 2009
- Rapid Functional Maturation of Nascent Dendritic SpinesNeuron, 2009
- Silent synapses and the emergence of a postsynaptic mechanism for LTPNature Reviews Neuroscience, 2008
- LTP Promotes a Selective Long-Term Stabilization and Clustering of Dendritic SpinesPLoS Biology, 2008
- Balancing Structure and Function at Hippocampal Dendritic SpinesAnnual Review of Neuroscience, 2008
- NMDA receptors inhibit synapse unsilencing during brain developmentProceedings of the National Academy of Sciences of the United States of America, 2008
- Synaptic modifications at the CA3-CA1 synapse after chronic AMPA receptor blockade in rat hippocampal slicesThe Journal of Physiology, 2007
- Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1Nature Neuroscience, 2006
- Genesis of dendritic spines: insights from ultrastructural and imaging studiesNature Reviews Neuroscience, 2004