Erythroid glucose transporters
- 1 May 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Hematology
- Vol. 16 (3), 165-172
- https://doi.org/10.1097/moh.0b013e328329905c
Abstract
Purpose of review Animals are heterotrophic and use sugar as their principal source of carbon. Every cell possesses at least one hexose transport system and of all cells, human erythrocytes express the highest level of the facilitative glucose transporter 1 (GLUT1). On the basis of human data, it was assumed that all mammalian erythrocytes express GLUT1 and that this transporter functions similarly in red cells of different species. Recent findings Analyses of erythrocytes from diverse mammalian species showed that GLUT1 is restricted to those few mammals who are unable to synthesize ascorbic acid from glucose comprising higher primates, guinea pigs, and fruit bats. In humans, erythroid differentiation results in a dramatic GLUT1-mediated increase in the transport of an oxidized form of vitamin C, L-dehydroascorbic acid. This preferential L-dehydroascorbic acid uptake is regulated by the association of GLUT1 with stomatin, an integral erythrocyte membrane protein. In species that produce ascorbic acid, erythroid GLUT1 expression appears to be limited to the fetal and neonatal period. In the case of murine erythrocytes, glucose transport function is thereafter achieved by GLUT4, a GLUT originally characterized by its sensitivity to insulin. Summary Recent research has shown that erythrocyte expression of GLUT-type transporters varies between mammalian species and that their functions in this context can differ. These data identify new arrangements of GLUT members in red cell metabolism.Keywords
This publication has 72 references indexed in Scilit:
- SLC2A9 Is a High-Capacity Urate Transporter in HumansPLoS Medicine, 2008
- Dematin and Adducin Provide a Novel Link between the Spectrin Cytoskeleton and Human Erythrocyte Membrane by Directly Interacting with Glucose Transporter-1Published by Elsevier BV ,2008
- Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cellsRetrovirology, 2007
- The GLUT4 Glucose TransporterCell Metabolism, 2007
- ATP-dependent sugar transport complexity in human erythrocytesAmerican Journal of Physiology-Cell Physiology, 2007
- Apoptosis Protection by the Epo Target Bcl-XL Allows Factor-Independent Differentiation of Primary ErythroblastsCurrent Biology, 2002
- Dehydroascorbic Acid Transport by GLUT4 in XenopusOocytes and Isolated Rat AdipocytesPublished by Elsevier BV ,2000
- GLUT1 glucose transporter gene transcription is repressed by Sp3. Evidence for a regulatory role of Sp3 during myogenesisJournal of Molecular Biology, 1999
- Regulation of glucose transport by hypoxiaAmerican Journal of Kidney Diseases, 1999
- On the Origin of Cancer CellsScience, 1956