Painful tonic heat stimulation induces GABA accumulation in the prefrontal cortex in man
- 1 March 2009
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain
- Vol. 142 (1), 89-93
- https://doi.org/10.1016/j.pain.2008.12.008
Abstract
Relatively little is known on pain-induced neurotransmitter release in the human cerebral cortex. We used proton magnetic resonance spectroscopy (1H-MRS) during tonic painful heat stimulation to test the hypothesis of increases in both glutamate and GABA, two neurotransmitters with a key role in pain processing. Using a 3 T MR scanner, we acquired spectra from the rostral anterior cingulate cortex (rACC) in 13 healthy right-handed subjects at rest and during painful heat stimulation. The painful stimulus consisted of a suprathreshold painful tonic heat pulse, which was delivered to the right upper leg via a fMRI-compatible Peltier element. Compared to non-painful stimulation, painful tonic heat was associated with a significant increase in GABA concentrations in the rACC. No changes in glutamate concentrations were detected during noxious stimulation. This study provides the first evidence that GABA is released in the human cerebral cortex during painful stimulation. The results are in line with animal findings on the role of GABA in pain processing and with studies in humans showing analgesic efficacy of GABA-related drugs in clinical pain conditions.Keywords
This publication has 39 references indexed in Scilit:
- Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back PainJournal of Neuroscience, 2006
- Distributions of transmitter receptors in the macaque cingulate cortexNeuroImage, 2005
- Dissociable Neural Responses Related to Pain Intensity, Stimulus Intensity, and Stimulus Awareness within the Anterior Cingulate Cortex: A Parametric Single-Trial Laser Functional Magnetic Resonance Imaging StudyJournal of Neuroscience, 2002
- Selective opiate modulation of nociceptive processing in the human brain.Journal of Neurophysiology, 2000
- Cognitive and emotional influences in anterior cingulate cortexTrends in Cognitive Sciences, 2000
- Mechanism underlying increased neuronal activity in the rat ventrolateral periaqueductal grey by a μ‐opioidThe Journal of Physiology, 1999
- Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in Macaque monkeysJournal of Comparative Neurology, 1998
- Limbic connections of the orbital and medial prefrontal cortex in macaque monkeysJournal of Comparative Neurology, 1995
- Distribution and kinetics of GABAB binding sites in rat central nervous system: A quantitative autoradiographic studyNeuroscience, 1990
- Stereotaxic Anterior Cingulotomy for Neuropsychiatric Illness and Intractable PainJournal of Neurosurgery, 1967