Personalized Approach to Growth Hormone Treatment: Clinical Use of Growth Prediction Models
Open Access
- 27 May 2013
- journal article
- review article
- Published by S. Karger AG in Hormone Research in Paediatrics
- Vol. 79 (5), 257-270
- https://doi.org/10.1159/000351025
Abstract
The goal of growth hormone (GH) treatment in a short child is to attain a fast catch-up growth toward the target height (TH) standard deviation score (SDS), followed by a maintenance phase, a proper pubertal height gain, and an adult height close to TH. The short-term response variable of GH treatment, first-year height velocity (HV) (cm/year or change in height SDS), can either be compared with GH response charts for diagnosis, age and gender, or with predicted HV based on prediction models. Three types of prediction models have been described: the Kabi International Growth Hormone Study models, the Gothenburg models and the Cologne model. With these models, 50-80% of the variance could be explained. When used prospectively, individualized dosing reduces the variation in growth response in comparison with a fixed dose per body weight. Insulin-like growth factor-I-based dose titration also led to a decrease in the variation. It is uncertain whether adding biochemical, genetic or proteomic markers may improve the accuracy of the prediction. Prediction models may lead to a more evidence-based approach to determine the GH dose regimen and may reduce the drug costs for GH treatment. There is a need for user-friendly software programs to make prediction models easily available in the clinic.Keywords
This publication has 67 references indexed in Scilit:
- Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)BMC Medical Informatics and Decision Making, 2011
- Adult Height in Children with Growth Hormone Deficiency: A Randomized, Controlled, Growth Hormone Dose-Response TrialHormone Research in Paediatrics, 2010
- The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in childrenBMC Medical Informatics and Decision Making, 2009
- Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal childrenProteome Science, 2009
- Anastrozole Increases Predicted Adult Height of Short Adolescent Males Treated with Growth Hormone: A Randomized, Placebo-Controlled, Multicenter Trial for One to Three YearsJournal of Clinical Endocrinology & Metabolism, 2008
- A proteomic approach identified growth hormone-dependent nutrition markers in children with idiopathic short statureProteome Science, 2008
- Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational ageBMC Medical Informatics and Decision Making, 2007
- The Effect of Pubertal Delay by GnRH Agonist in GH-Deficient Children on Final HeightJournal of Clinical Endocrinology & Metabolism, 2001
- High Dose Recombinant Human Growth Hormone (GH) Treatment of GH-Deficient Patients in Puberty Increases Near-Final Height: A Randomized, Multicenter TrialJournal of Clinical Endocrinology & Metabolism, 2000
- Growth Response to Growth Hormone (GH) Treatment Relates to Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 in Short Children with Various GH Secretion CapacitiesJournal of Clinical Endocrinology & Metabolism, 1997