Dynamic molecular processes mediate cellular mechanotransduction
Top Cited Papers
- 20 July 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 475 (7356), 316-323
- https://doi.org/10.1038/nature10316
Abstract
Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion complexes and the cytoskeleton. Recent work has demonstrated that these structures are dynamic, undergoing assembly, disassembly and movement, even when ostensibly stable. An emerging insight is that transduction of forces into biochemical signals occurs within the context of these processes. This framework helps to explain how forces of varying strengths or dynamic characteristics regulate distinct signalling pathways.Keywords
This publication has 96 references indexed in Scilit:
- Forcing form and function: biomechanical regulation of tumor evolutionTrends in Cell Biology, 2011
- Conserved F-actin dynamics and force transmission at cell adhesionsCurrent Opinion in Cell Biology, 2010
- A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and RepairDevelopmental Cell, 2010
- Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamicsNature, 2010
- Strength Dependence of Cadherin-Mediated AdhesionsBiophysical Journal, 2010
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- Cell adhesion receptors in mechanotransductionCurrent Opinion in Cell Biology, 2008
- Universal physical responses to stretch in the living cellNature, 2007
- Reversible stress softening of actin networksNature, 2007
- Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasCell, 2006