Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing
- 15 May 2011
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 186 (10), 5543-5547
- https://doi.org/10.4049/jimmunol.1003865
Abstract
Endogenous microparticles (MPs) were systematically profiled during the time course of self-limited inflammation. Precursors for specialized proresolving lipid mediators were identified in MPs from inflammatory exudates using liquid chromatography tandem mass spectrometry-based metabolomics. Hence, we postulated that formation of anti-inflammatory and proresolving lipid mediators could underlie beneficial effects attributed to MPs and that this process could serve as a basis for biomimicry. Using human neutrophil-derived MPs, we constructed novel nanoparticles (NPs) containing aspirin-triggered resolvin D1 or a lipoxin A4 analog. Enriched NPs dramatically reduced polymorphonuclear cell influx in murine peritonitis, shortened resolution intervals, and exhibited proresolving actions accelerating keratinocyte healing. The enriched NPs protected against inflammation in the temporomandibular joint. These findings indicate that humanized NPs, termed nano-proresolving medicines, are mimetics of endogenous resolving mechanisms, possess potent beneficial bioactions, can reduce nanotoxicity, and offer new therapeutic approaches.Keywords
This publication has 18 references indexed in Scilit:
- Measuring persistent temporomandibular joint nociception in rats and two mice strainsPhysiology & Behavior, 2010
- Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle ProductionScience, 2010
- Resolvin D1 binds human phagocytes with evidence for proresolving receptorsProceedings of the National Academy of Sciences of the United States of America, 2010
- Anti-inflammatory and pro-resolving properties of benzo-lipoxin A4 analogsProstaglandins, Leukotrienes & Essential Fatty Acids, 2009
- Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actionsThe Journal of Experimental Medicine, 2008
- Temporomandibular DisordersThe New England Journal of Medicine, 2008
- Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in ResolutionThe Journal of Immunology, 2008
- Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory propertiesBioorganic & Medicinal Chemistry Letters, 2008
- Active Intracellular Transport of Nanoparticles: Opportunity or Threat?ACS Nano, 2007
- Mediator Lipidomics: Search Algorithms for Eicosanoids, Resolvins, and ProtectinsMethods in Enzymology, 2007