Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity
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- 6 October 2014
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 111 (42), E4485-E4493
- https://doi.org/10.1073/pnas.1415174111
Abstract
Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of the present study was to explore whether changes in gut permeability are linked to gut-microbiota composition and activity in alcohol-dependent subjects. We also investigated whether gut dysfunction is associated with the psychological symptoms of alcohol dependence. Finally, we tested the reversibility of the biological and behavioral parameters after a short-term detoxification program. We found that some, but not all, alcohol-dependent subjects developed gut leakiness, which was associated with higher scores of depression, anxiety, and alcohol craving after 3 wk of abstinence, which may be important psychological factors of relapse. Moreover, subjects with increased gut permeability also had altered composition and activity of the gut microbiota. These results suggest the existence of a gut–brain axis in alcohol dependence, which implicates the gut microbiota as an actor in the gut barrier and in behavioral disorders. Thus, the gut microbiota seems to be a previously unidentified target in the management of alcohol dependence.Keywords
This publication has 77 references indexed in Scilit:
- Normal gut microbiota modulates brain development and behaviorProceedings of the National Academy of Sciences of the United States of America, 2011
- Enteric dysbiosis associated with a mouse model of alcoholic liver diseaseHepatology, 2010
- Pyrosequencing study of fecal microflora of autistic and control childrenAnaerobe, 2010
- The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammationProceedings of the National Academy of Sciences of the United States of America, 2009
- Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localizationToxicology and Applied Pharmacology, 2009
- Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot studyAlcohol, 2008
- Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patientsProceedings of the National Academy of Sciences of the United States of America, 2008
- Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in miceMolecular Psychiatry, 2008
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- An algorithm for the grading of activity in chronic hepatitis CHepatology, 1996