International meeting: new diagnostic tests are urgently needed to treat patients with Chagas disease
Open Access
- 1 June 2008
- journal article
- review article
- Published by FapUNIFESP (SciELO) in Revista da Sociedade Brasileira de Medicina Tropical
- Vol. 41 (3), 315-319
- https://doi.org/10.1590/s0037-86822008000300020
Abstract
Trypanosoma cruzi infection is often not detected early on or actively diagnosed, partly because most infected individuals are either asymptomatic or oligosymptomatic. Moreover, in most places, neither blood banks nor healthcare units offer diagnostic confirmation or treatment access. By the time patients present clinical manifestations of advanced chronic Chagas disease, specific treatment with current drugs usually has limited effectiveness. Better-quality serological assays are urgently needed, especially rapid diagnostic tests for diagnosis patients in both acute and chronic phases, as well as for confirming that a parasitological cure has been achieved. Some new antigen combinations look promising and it is important to assess which ones are potentially the best, together with their requirements in terms of investigation and development. In August 2007, a group of specialized researchers and healthcare professionals met to discuss the state of Chagas infection diagnosis and to build a consensus for a plan of action to develop efficient, affordable, accessible and easy-to-use diagnostic tests for Chagas disease. This technical report presents the conclusions from that meeting.Keywords
This publication has 11 references indexed in Scilit:
- Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI centuryMemórias do Instituto Oswaldo Cruz, 2007
- Evaluation of Serological Tests To Identify Trypanosoma cruzi Infection in Humans and Determine Cross-Reactivity with Trypanosoma rangeli and Leishmania sppClinical and Vaccine Immunology, 2007
- Immunoblot Assay Using Recombinant Antigens as a Supplemental Test To Confirm the Presence of Antibodies to Trypanosoma cruziClinical and Vaccine Immunology, 2007
- Validation of a Rapid and Reliable Test for Diagnosis of Chagas' Disease by Detection of Trypanosoma cruzi -Specific Antibodies in Blood of Donors and Patients in Central AmericaJournal of Clinical Microbiology, 2005
- Chagas’ disease diagnosis: a multicentric evaluation of Chagas Stat-Pak, a rapid immunochromatographic assay with recombinant proteins of Trypanosoma cruziDiagnostic Microbiology and Infectious Disease, 2003
- Chagas disease: recombinant Trypanosoma cruzi antigens for serological diagnosisTrends in Parasitology, 2001
- Screening and confirmation in Chagas disease serology - a contributionMemórias do Instituto Oswaldo Cruz, 1999
- A recombinant peptide antigen line immunoassay optimized for the confirmation of Chagas' diseaseTransfusion, 1999
- Increased Specificity of Serodiagnosis of Chagas' Disease by Detection of Antibody to the 72- and 90-Kilodalton Glycoproteins of Trypanosoma cruziThe Journal of Infectious Diseases, 1987
- Antibody Levels to Trypanosoma Cruzi in Infected Patients with and without Evidence of Chronic Chagas' Disease *The American Journal of Tropical Medicine and Hygiene, 1982