The importance of microglia in the development of the vasculature in the central nervous system
Open Access
- 1 January 2013
- journal article
- Published by Publiverse Online S.R.L in Vascular Cell
- Vol. 5 (1), 4
- https://doi.org/10.1186/2045-824x-5-4
Abstract
The body’s vascular system is thought to have developed in order to supply oxygen and nutrients to cells beyond the reach of simple diffusion. Hence, relative hypoxia in the growing central nervous system (CNS) is a major driving force for the ingression and refinement of the complex vascular bed that serves it. However, even before the establishment of this CNS vascular system, CNS-specific macrophages (microglia) migrate into the brain. Recent studies in mice point to the fundamental importance of microglia in shaping CNS vasculature during development, and re-shaping these vessels during pathological insults. In this review, we discuss the origin of CNS microglia and their localization within the brain based on data obtained in mice. We then review evidence supporting a functional role of these microglia in developmental angiogenesis. Although pathologic processes such as CNS ischemia may subvert the developmental functions of microglia/macrophages with significant effects on brain neo-angiogenesis, we have left this topic to other recent reviews (Nat Rev Immunol 9:259–270, 2009 and Trends Mol Med 17:743–752, 2011).Keywords
This publication has 58 references indexed in Scilit:
- Protective and pathogenic functions of macrophage subsetsNature Reviews Immunology, 2011
- Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in miceBlood, 2011
- VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signallingNature, 2011
- Semaphorin 3E–Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanismGenes & Development, 2011
- Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cellsNature, 2011
- Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell inductionBlood, 2010
- The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch SignalingDevelopmental Cell, 2010
- Haematopoietic stem cells derive directly from aortic endothelium during developmentNature, 2010
- Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brainNature Neuroscience, 2008
- Notch expression patterns in the retina: An eye on receptor–ligand distribution during angiogenesisGene Expression Patterns, 2007