Vasoactive intestinal peptide (VIP) cells in the pancreas and gastro-intestinal mucosa
- 1 January 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Histochemistry and Cell Biology
- Vol. 50 (3), 217-227
- https://doi.org/10.1007/bf00491069
Abstract
Using antibodies against pure porcine VIP in immunoperoxidase and immunofluorescence tests, VIP-immunoreactive cells have been detected in the pancreas—especially in the islets—and gastrointestinal mucosa of the dog, guinea-pig and man. VIP immunoreactive cells were widely distributed in these tissues, never being numerous at any site. Some parallelism has been noted between such cells and ultrastructurally identified D1 cells of the pancreas and gastrointestinal mucosa. The presence of VIP cells in normal pancreas may help explain the occurrence of pancreatic endocrine tumors producing VIP.Keywords
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