PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex
- 27 July 2004
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 381 (3), 587-592
- https://doi.org/10.1042/bj20040846
Abstract
MAKAP (muscle-selective A-kinase-anchoring protein) co-ordinates a cAMP-sensitive negative-feedback loop comprising PKA (cAMP-dependent protein kinase) and the cAMP-selective PDE4D3 (phosphodiesterase 4D3). In vitro and cellular experiments demonstrate that PKA-phosphorylation of PDE4D3 on Ser-13 increases the affinity of PDE4D3 for mAKAP. Our data suggest that activation of mAKAP-anchored PKA enhances the recruitment of PDE4D3, allowing for quicker signal termination.Keywords
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