Synthesis and in vitro Antimicrobial Evaluation of 5‐(1‐Methyl‐5‐nitro‐2‐imidazolyl)‐4H‐1, 2, 4‐triazoles
- 23 December 2002
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 335 (10), 495-499
- https://doi.org/10.1002/ardp.200290004
Abstract
The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4H‐1, 2, 4‐triazoles (4a—6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5—1 μg/mL and moderate effects against Staphylococcus aureus.Keywords
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