Genetics, Pathology, and Clinics of Familial Gastric Cancer
- 1 January 2006
- journal article
- review article
- Published by SAGE Publications in International Journal of Surgical Pathology
- Vol. 14 (1), 21-33
- https://doi.org/10.1177/106689690601400105
Abstract
Gastric cancer is relatively common worldwide, mainly in its sporadic form, but familial aggregation of the disease may be seen in approximately 10% of the cases. This suggests a genetic cause for the cancer in those families that has not been identified in most cases. Despite all efforts to determine its genetic basis, a single syndrome has been characterized-the hereditary diffuse gastric cancer (HDGC)-which is specifically associated with CDH1 (E-cadherin) germline mutations in one third of the families. The other two thirds and all the gastric cancer families not fulfilling the HDGC criteria remain without molecular diagnosis. In this article we review the state of the art of familial gastric cancer regarding the molecular aspects, the clinical criteria, the pathology features, and the management recommendations described so far to be associated with this cancer disease.Keywords
This publication has 74 references indexed in Scilit:
- E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patientsEuropean Journal Of Cancer, 2004
- Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteriaJournal of Medical Genetics, 2004
- Genetic Screening for Familial Gastric CancerHereditary Cancer in Clinical Practice, 2004
- A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinomaGastroenterology, 2003
- Genetic screening for hereditary diffuse gastric cancerExpert Review of Molecular Diagnostics, 2003
- Helicobacter pylori and Interleukin 1 Genotyping: An Opportunity to Identify High-Risk Individuals for Gastric CarcinomaJNCI Journal of the National Cancer Institute, 2002
- Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindredHuman Mutation, 2002
- Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutationsCarcinogenesis: Integrative Cancer Research, 1999
- E-cadherin germline mutations in familial gastric cancerNature, 1998
- Cadherin Cell Adhesion Receptors as a Morphogenetic RegulatorScience, 1991