Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry
- 1 March 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 23 (1), 531-556
- https://doi.org/10.1146/annurev.neuro.23.1.531
Abstract
The diverse cell types in the nervous system are derived from neural progenitor cells. Neural progenitors can undergo symmetric divisions to expand cell population or asymmetric divisions to generate diverse cell types. Furthermore, neural progenitors must exit the cell cycle in a developmentally regulated manner to allow for terminal differentiation. The patterns of neural progenitor divisions have been characterized in vertebrates and invertebrates. During the course of nervous system development, extrinsic and intrinsic cues dictate the division patterns of neural progenitors by influencing their cell cycle behavior and cellular polarity. The identification in Drosophila of asymmetrically distributed fate determinants, adapter molecules, and polarity organizing molecules that participate in asymmetric neural progenitor divisions should provide points of entry for studying similar asymmetric divisions in vertebrates.Keywords
This publication has 99 references indexed in Scilit:
- Intrinsic Polarity of Mammalian Neuroepithelial CellsMolecular and Cellular Neuroscience, 1998
- Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fateCurrent Biology, 1996
- Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and NotchNeuron, 1996
- Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell FatesNeuron, 1996
- Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesisCell, 1995
- Neurogenesis in an adult insect brain and its hormonal controlNature, 1994
- Cloning of the Drosophila prospero gene and its expression in ganglion mother cellsBiochemical and Biophysical Research Communications, 1992
- A dual function of the Notch gene in Drosophila sensillum developmentDevelopmental Biology, 1990
- Clonally Related Cortical Cells Show Several Migration PatternsScience, 1988
- Microdissection studies on the polarity of unequal division in grasshopper neuroblastsExperimental Cell Research, 1986