Norepinephrine Inhibits Human Natural Killer Cell Activity in Vitro
- 1 January 1991
- journal article
- research article
- Published by Informa UK Limited in International Journal of Neuroscience
- Vol. 58 (1-2), 127-131
- https://doi.org/10.3109/00207459108987189
Abstract
The effect of norepinephrine on human NK cell activity was investigated using a flow cytometry assay. NK cell activity was found to be inhibited by direct addition of norepinephrine to lymphocyte/target cell mixtures in a dose-dependent fashion. This inhibitory effect of norepinephrine was blocked by propranolol but not by atenolol. The results suggest that norepinephrine has a negative influence on NK cell activity and that the effect of norepinephrine is mediated via β2-adrenoceptors.Keywords
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